Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL530008 | 1.00 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL1921853 | 1.00 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL1920944 | 1.00 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL9341964 | 0.96 | SLC7A5 (0.60) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL28159330 | 0.95 | SLC7A5 (0.58) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3485478 | 0.94 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL571284 | 0.94 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3303402 | 0.94 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL21925058 | 0.94 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL1921493 | 0.94 | SLC7A5 (0.57) | SLC7A5ITGB3ITGA2BGSRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106940347-A | The method that simultaneous quantitative detects sea-tangle bioconversion broth small molecular blood pressure lowering peptide | 福建农林大学 | 2017-07-11 | — | — | CN | claimed |
| US-20100298227-A1 | Treatment of autoimmune conditions with Copolymer 1 and related copolymers | President and Fellows of Harvard College and Yeda Research | 2010-11-25 | — | — | US | claimed |
| US-9066905-B2 | Synthetic peptides and methods of use for autoimmune disease therapies | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-06-30 | — | — | US | disclosed |
| US-20080207526-A1 | Synthetic peptides and methods of use for autoimmune disease therapies | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2008-08-28 | — | — | US | disclosed |
| EP-1105414-A2 | SYNTHETIC PEPTIDES AND METHODS OF USE FOR AUTOIMMUNE DISEASE THERAPIES | President And Fellows of Harvard College (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000005249-A2 | SYNTHETIC PEPTIDES AND METHODS OF USE FOR AUTOIMMUNE DISEASE THERAPIES | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-02-03 | — | — | WO | disclosed |