Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.71 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.71 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.71 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.71 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | RNF4 | P78317 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4984163 | 1.00 | S1PR1 (0.71) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL4984174 | 1.00 | S1PR1 (0.71) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL14263188 | 0.93 | PDK1 (0.64) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL14263246 | 0.92 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL4983181 | 0.90 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL4983172 | 0.90 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL4981394 | 0.88 | S1PR1 (0.57) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL5356124 | 0.88 | S1PR1 (0.57) | S1PR1S1PR3S1PR4S1PR5PDK1 | |
| SCHEMBL4979844 | 0.87 | S1PR1 (0.74) | S1PR1S1PR3S1PR4S1PR5SMN1; SMN2 | |
| SCHEMBL4979834 | 0.87 | S1PR1 (0.74) | S1PR1S1PR3S1PR4S1PR5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241812-B2 | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity | PRAECIS PHARMACEUTICALS, INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-20060135786-A1 | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity | PRAECIS PHAMACEUTICALS, INC. (US) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135786-A1 | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity | S1PR1, S1PR2, S1PR3 | S1PR1 1/4885S1PR3 3/4885S1PR4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.