Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.67 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.67 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.67 |
| ▸ | F2 | P00734 | 2/20 | 0.67 |
| ▸ | PLG | P00747 | 2/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368509 | 0.91 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5363958 | 0.91 | TPSAB1 (0.70) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5368197 | 0.90 | TPSAB1 (0.72) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5361028 | 0.89 | TPSAB1 (0.70) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5361037 | 0.89 | TPSAB1 (0.70) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5359992 | 0.88 | TPSAB1 (0.69) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5369674 | 0.88 | TPSAB1 (0.72) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5360988 | 0.88 | TPSAB1 (0.61) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL14425287 | 0.87 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1F2PLG | |
| SCHEMBL5367862 | 0.87 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1F2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1390034-A4 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1390034-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK SHARP & DOHME CORP. | 2003-06-26 | — | — | US | disclosed |
| WO-2002080928-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | GRIN1, GRIN2B, GRIN2A | TPSAB1 2199/4885TPSD1 2227/4885TPSG1 3949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.