Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535936 | 0.89 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL535810 | 0.81 | GABRA5 (0.41) | GABRA5 | |
| SCHEMBL535888 | 0.80 | GABRA5 (0.67) | GABRA5 | |
| SCHEMBL535838 | 0.80 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL535755 | 0.80 | GABRA5 (0.76) | GABRA5 | |
| SCHEMBL536348 | 0.77 | GABRA5 (0.78) | GABRA5 | |
| SCHEMBL2926911 | 0.76 | GABRA5 (0.70) | GABRA5 | |
| SCHEMBL536246 | 0.75 | GABRA5 (0.79) | GABRA5 | |
| SCHEMBL536319 | 0.75 | GABRA5 (0.79) | GABRA5 | |
| SCHEMBL536300 | 0.74 | GABRA5 (0.79) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414354-A1 | Hydroxy-methyl isoxazole derivatives as gaba a modulators | F. Hoffmann-La Roche AG (CH) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112475-A1 | HYDROXY-METHYL ISOXAZOLE DERIVATIVES AS GABA A MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-07 | — | — | WO | disclosed |