Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.43 |
| ▸ | FAP | Q12884 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362704 | 0.83 | DPP4 (0.64) | DPP4CHRM1FAP | |
| SCHEMBL5362379 | 0.83 | DPP4 (0.41) | DPP4CHRM1FAP | |
| SCHEMBL4249672 | 0.83 | DPP4 (0.44) | DPP4CHRM1FAPCYP3A4 | |
| SCHEMBL4252373 | 0.81 | DPP4 (0.45) | DPP4CHRM1FAPCYP3A4 | |
| SCHEMBL5359347 | 0.81 | DPP4 (0.42) | DPP4CHRM1FAPCYP3A4 | |
| SCHEMBL5361062 | 0.81 | DPP4 (0.66) | DPP4CHRM1FAP | |
| SCHEMBL3917633 | 0.79 | DPP4 (0.54) | DPP4CHRM1FAPCYP3A4 | |
| SCHEMBL4070957 | 0.79 | DPP4 (0.68) | DPP4CHRM1 | |
| SCHEMBL4069497 | 0.79 | DPP4 (0.68) | DPP4CHRM1 | |
| SCHEMBL3207468 | 0.76 | DPP4 (0.71) | DPP4CHRM1FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217711-B2 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-15 | — | — | US | disclosed |