Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366056 | 0.87 | DPP4 (0.40) | DPP4CHRM1FAPPKMPKLR | |
| SCHEMBL5358438 | 0.84 | DPP4 (0.39) | DPP4CHRM1FAPPKMPKLR | |
| SCHEMBL5370066 | 0.83 | DPP4 (0.62) | DPP4CHRM1FAP | |
| SCHEMBL5358909 | 0.83 | DPP4 (0.43) | DPP4CHRM1FAP | |
| SCHEMBL4248894 | 0.81 | DPP4 (0.43) | DPP4CHRM1 | |
| SCHEMBL5359347 | 0.80 | DPP4 (0.42) | DPP4CHRM1FAP | |
| SCHEMBL5365295 | 0.79 | DPP4 (0.41) | DPP4CHRM1ALDH1A1 | |
| SCHEMBL3975290 | 0.78 | DPP4 (0.50) | DPP4CHRM1FAPPKMALDH1A1 | |
| SCHEMBL1069921 | 0.78 | DPP4 (0.68) | DPP4CHRM1 | |
| SCHEMBL8278518 | 0.78 | DPP4 (0.68) | DPP4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217711-B2 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-15 | — | — | US | disclosed |