Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.89 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355698 | 0.94 | KDR (1.00) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL5355363 | 0.86 | KDR (0.85) | KDRCHEK1MEN1KMT2ACA12 | |
| SCHEMBL5355082 | 0.84 | KDR (0.73) | KDRCHEK1VCP | |
| SCHEMBL5357068 | 0.83 | KDR (0.88) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL5359215 | 0.82 | KDR (0.67) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL14590416 | 0.82 | KDR (0.88) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL5362169 | 0.82 | KDR (0.77) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL5362580 | 0.81 | KDR (0.70) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL5367396 | 0.76 | KDR (1.00) | KDRCHEK1MEN1KMT2AHSD17B10 | |
| SCHEMBL25727906 | 0.76 | KDR (0.61) | KDRMEN1KMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |