Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355698 | 0.84 | KDR (1.00) | KDRCHEK1 | |
| SCHEMBL5358982 | 0.84 | KDR (0.89) | KDRCHEK1VCP | |
| SCHEMBL5367711 | 0.83 | KDR (0.70) | KDRCHEK1HTR2BHTR1A | |
| SCHEMBL14590417 | 0.82 | KDR (0.71) | KDRCHEK1 | |
| SCHEMBL5355458 | 0.78 | KDR (0.54) | KDRCHEK1ALOX5APFEN1 | |
| SCHEMBL5362169 | 0.78 | KDR (0.77) | KDRCHEK1ALOX5APFEN1 | |
| SCHEMBL5362580 | 0.77 | KDR (0.70) | KDRCHEK1ALOX5APFEN1 | |
| SCHEMBL6795564 | 0.76 | MEN1 (0.60) | HTR2BHTR6HTR1ADRD2HTR1D | |
| SCHEMBL5355363 | 0.76 | KDR (0.85) | KDRCHEK1 | |
| SCHEMBL5359215 | 0.75 | KDR (0.67) | KDRCHEK1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |