⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541394 | 0.79 | — | — | |
| SCHEMBL4775922 | 0.75 | — | — | |
| SCHEMBL1642155 | 0.72 | TSHR (0.45) | — | |
| SCHEMBL6508099 | 0.72 | TSHR (0.45) | — | |
| SCHEMBL514292 | 0.72 | TSHR (0.45) | — | |
| SCHEMBL15109080 | 0.72 | TSHR (0.45) | — | |
| SCHEMBL29726981 | 0.72 | TSHR (0.45) | — | |
| SCHEMBL8999536 | 0.72 | TSHR (0.45) | — | |
| SCHEMBL514390 | 0.72 | ACHE (0.42) | — | |
| SCHEMBL5320697 | 0.72 | TP53 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615544-A1 | ANTITUMORAL COMPOUNDS | Pharma Mar S.A. (ES) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018197663-A1 | ANTITUMORAL COMPOUNDS | PHARMA MAR, S.A. (ES) | 2018-11-01 | — | — | WO | disclosed |
| WO-2018167270-A1 | ANTICANCER COMPOUNDS | PHARMA MAR, S.A. (ES) | 2018-09-20 | — | — | WO | disclosed |
| CN-107873031-A | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-04-03 | — | — | CN | disclosed |
| EP-3174870-A1 | THIENO [3,2-D]PYRIMIDINE, FURO [3,2,D]PYRIMIDINE, AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016018697-A1 | THIENO [3,2-D] PYRIMIDINE, FURO [3,2,D] PYRIMIDINE, AND PYRROLO [3,2-D] PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2016-02-04 | — | — | WO | disclosed |
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-102448955-B | Aminopyrimidine Anticancer Compounds | OSI PHARM INC | 2014-06-18 | — | — | CN | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |
| US-4414210-A | 2-Hydroxyarylethyltriazole fungicides | ROHM AND HAAS COMPANY (US) | 1983-11-08 | — | — | US | disclosed |
| US-4413003-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1983-11-01 | — | — | US | disclosed |
| US-3869507-A | MULTISTAGE | MERCK & CO INC | 1975-03-04 | — | — | US | disclosed |
| US-3868415-A | MULTISTAGE FROM 5-FLUORO-2-METHYL-INDANE-1,3-DIONE AND A MALONATE | MERCK & CO INC | 1975-02-25 | — | — | US | disclosed |