Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.54 |
| ▸ | FAP | Q12884 | 1/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.54 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 12/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | MC3R | P41968 | 1/20 | 0.49 |
| ▸ | MC1R | Q01726 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366185 | 0.86 | POLB (0.64) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL6583576 | 0.86 | POLB (0.64) | DPP4DPP7FAPDPP8DPP9 | |
| Hydrochloric Acid SCHEMBL6166049 | 0.85 | DPP7 (0.67) | DPP4DPP7FAPDPP8DPP9 | |
| Hydrochloric Acid SCHEMBL6166042 | 0.85 | DPP7 (0.67) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL5359350 | 0.84 | DPP4 (0.57) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL4902903 | 0.80 | AKT1 (0.60) | DPP4DPP7AKT1AKT2AKT1S1 | |
| SCHEMBL5059867 | 0.80 | AKT1 (0.60) | DPP4AKT1AKT2AKT1S1AKT3 | |
| SCHEMBL4773399 | 0.78 | DPP4 (0.51) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL21037177 | 0.77 | AKT1 (0.48) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL5368002 | 0.76 | GAA (0.69) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |