Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 2/20 | 0.55 |
| ▸ | FAP | Q12884 | 1/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583576 | 1.00 | POLB (0.64) | POLBHDAC8OPRD1SMN1; SMN2CYP2C19 | |
| SCHEMBL5359348 | 0.86 | DPP4 (0.57) | POLBDPP4FAPDPP8DPP9 | |
| SCHEMBL5367387 | 0.86 | SMN1; SMN2 (0.58) | POLBSMN1; SMN2CYP2C19TDP1ALDH1A1 | |
| SCHEMBL6161830 | 0.86 | OPRD1 (0.65) | POLBHDAC8OPRD1TACR1DPP4 | |
| SCHEMBL3133533 | 0.86 | OPRD1 (0.65) | POLBHDAC8OPRD1TACR1DPP4 | |
| SCHEMBL5374449 | 0.85 | HSD17B10 (0.64) | POLBSMN1; SMN2CYP2C19TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6165745 | 0.84 | HDAC8 (0.63) | POLBHDAC8OPRD1TACR1DPP4 | |
| SCHEMBL7360693 | 0.84 | HPGD (0.66) | POLBHDAC8OPRD1TACR1DPP4 | |
| Hydrochloric Acid SCHEMBL6163295 | 0.84 | HDAC8 (0.63) | POLBHDAC8OPRD1TACR1DPP4 | |
| Hydrochloric Acid SCHEMBL6163301 | 0.84 | HDAC8 (0.63) | POLBHDAC8OPRD1TACR1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| CN-1178524-A | Di-substituted 1, 4 -piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA (IT) | 1998-04-08 | — | — | CN | disclosed |