Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535981 | 1.00 | GABRA5 (0.57) | GABRA5 | |
| SCHEMBL536293 | 0.97 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL536292 | 0.97 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL535920 | 0.92 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL535977 | 0.90 | GABRA5 (0.68) | GABRA5 | |
| SCHEMBL535976 | 0.90 | GABRA5 (0.68) | GABRA5 | |
| SCHEMBL535942 | 0.88 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL535943 | 0.88 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL535899 | 0.87 | GABRA5 (0.75) | GABRA5 | |
| SCHEMBL535900 | 0.87 | GABRA5 (0.75) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414354-A1 | Hydroxy-methyl isoxazole derivatives as gaba a modulators | F. Hoffmann-La Roche AG (CH) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112475-A1 | HYDROXY-METHYL ISOXAZOLE DERIVATIVES AS GABA A MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-07 | — | — | WO | disclosed |