Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 3/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23453046 | 0.79 | TMIGD3 (0.40) | HDAC1HDAC2TDP1 | |
| SCHEMBL8649567 | 0.79 | CKS1B (0.40) | HDAC1HDAC2CKS1BSKP1SKP2 | |
| SCHEMBL6803680 | 0.77 | TDP1 (0.40) | HDAC1HDAC2DOT1LCKS1BSKP1 | |
| SCHEMBL6046940 | 0.77 | HDAC1 (0.43) | HDAC1CKS1BSKP1SKP2BRD4 | |
| SCHEMBL13660679 | 0.76 | PDE4A (0.42) | HDAC1HDAC2TDP1 | |
| SCHEMBL23453050 | 0.75 | TDP1 (0.40) | HDAC1HDAC2CKS1BSKP1SKP2 | |
| SCHEMBL1404474 | 0.75 | DAPK1 (0.47) | HDAC1HDAC2CKS1BSKP1SKP2 | |
| SCHEMBL12712246 | 0.74 | CCNE2 (0.33) | HDAC1HDAC2DOT1LCKS1BSKP1 | |
| SCHEMBL18087389 | 0.74 | FLT4 (0.35) | DOT1LCKS1BSKP1SKP2 | |
| SCHEMBL23453058 | 0.73 | HDAC1 (0.41) | HDAC1HDAC2CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223833-B1 | Peptide nucleic acid conjugates | ISIS PHARMACEUTICALS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-0804456-B1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-0804456-A4 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0804456-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011205-A9 | PEPTIDE NUCLEIC ACID CONJUGATES | — | 1996-05-30 | — | — | WO | disclosed |
| WO-1996011205-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-18 | — | — | WO | disclosed |