Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505290 | 0.69 | HTT (0.36) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL536038 | 0.66 | MEN1 (0.31) | ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL6118859 | 0.60 | KDM4E (0.49) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL6118855 | 0.59 | KDM4E (0.55) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL9430926 | 0.59 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL25591913 | 0.58 | ALDH1A1 (0.50) | KDM4EALDH1A1HTTPOLBKMT2A | |
| SCHEMBL12731290 | 0.57 | KDM4E (0.43) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL6472720 | 0.57 | KDM4E (0.43) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL30630386 | 0.56 | MRGPRX4 (0.50) | KDM4EALDH1A1HTTPOLBKMT2A | |
| SCHEMBL29100989 | 0.56 | MRGPRX4 (0.50) | KDM4EALDH1A1HTTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |