Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 7/20 | 0.53 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358368 | 0.95 | MOGAT2 (0.61) | MOGAT2LRRK2GSK3BMGAT2 | |
| SCHEMBL7140002 | 0.92 | MOGAT2 (0.56) | MOGAT2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5370221 | 0.91 | MOGAT2 (0.57) | MOGAT2MGAT2 | |
| SCHEMBL5362785 | 0.90 | MOGAT2 (0.56) | MOGAT2MGAT2PLK4 | |
| SCHEMBL5361465 | 0.90 | MOGAT2 (0.59) | MOGAT2LRRK2GSK3BMGAT2 | |
| SCHEMBL5357745 | 0.90 | MOGAT2 (0.58) | MOGAT2LRRK2GSK3BMGAT2 | |
| SCHEMBL5359548 | 0.90 | MOGAT2 (0.54) | MOGAT2GSK3BMGAT2 | |
| SCHEMBL7139561 | 0.89 | MOGAT2 (0.56) | MOGAT2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5362279 | 0.89 | MOGAT2 (0.57) | MOGAT2MGAT2 | |
| SCHEMBL7130952 | 0.89 | MOGAT2 (0.55) | MOGAT2LRRK2GSK3BMGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MOGAT2 1159/4885PSEN1 3695/4885PSEN2 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.