Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 11/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | PAK4 | O96013 | 2/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4096592 | 0.89 | ZAP70 (0.78) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4089370 | 0.89 | ALK (0.68) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4093702 | 0.88 | ALK (0.70) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4100115 | 0.87 | ALK (0.63) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4089503 | 0.86 | ALK (0.70) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4095865 | 0.86 | ULK1 (0.74) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4100866 | 0.85 | ALK (0.66) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4103561 | 0.85 | ULK1 (0.67) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4099025 | 0.81 | EGFR (0.71) | ZAP70ALKEGFRIGF1RPTK2 | |
| SCHEMBL4096523 | 0.80 | ALK (0.80) | ZAP70ALKEGFRIGF1RPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784392-A2 | PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021454-A2 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2006-03-02 | — | — | WO | disclosed |