Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.57 |
| ▸ | RARA | P10276 | 2/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.41 |
| ▸ | RARG | P13631 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359410 | 0.73 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL5359405 | 0.73 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL5356754 | 0.72 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL14212730 | 0.72 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL5356750 | 0.72 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL29503658 | 0.72 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL5364757 | 0.69 | CYP26A1 (0.74) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL7872156 | 0.69 | CYP26A1 (0.74) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL5359919 | 0.66 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL5359932 | 0.66 | RXRA (1.00) | RXRARARACYP26A1CYP3A4CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173134-B2 | Selective RXR ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-06 | — | — | US | disclosed |