Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355475 | 0.92 | KDR (0.68) | KDRPKMTDP1MEN1KMT2A | |
| SCHEMBL5352066 | 0.89 | KDR (0.64) | KDRPKMTDP1MEN1KMT2A | |
| SCHEMBL5359215 | 0.83 | KDR (0.67) | KDRTDP1MEN1KMT2APOLB | |
| SCHEMBL5370747 | 0.82 | KDR (0.67) | KDRPKMTDP1MEN1KMT2A | |
| SCHEMBL14590416 | 0.81 | KDR (0.88) | KDRPKMMEN1KMT2APOLB | |
| SCHEMBL5355012 | 0.79 | KDR (1.00) | KDRPKMMEN1KMT2APOLB | |
| SCHEMBL143989 | 0.77 | ALK (0.45) | KDRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL14559410 | 0.76 | KDR (0.57) | KDRMEN1KMT2ABLMKDM4E | |
| SCHEMBL5362580 | 0.76 | KDR (0.70) | KDRPKMTDP1MEN1KMT2A | |
| SCHEMBL5356996 | 0.74 | KDR (0.79) | KDRPKMTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |