SCHEMBL5362674

SCHEMBL5362674

CCOC(=O)c1nn(COC(=O)C(C)(C)C)cc1CBr

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.40
ADORA2A P29274 3/20 0.40
ADORA1 P30542 3/20 0.40
NPC1 O15118 7/20 0.38
RAB9A P51151 6/20 0.38
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
MAPT P10636 1/20 0.37
CYP2C19 P33261 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CYP3A4 P08684 1/20 0.37
KDM4E B2RXH2 3/20 0.36
LMNA P02545 1/20 0.36
ELANE P08246 2/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 2/20 0.35
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14347730 0.91 ADORA3 (0.43) ADORA3ADORA2AADORA1NPC1RAB9A
SCHEMBL5357082 0.83 ADORA3 (0.43) ADORA3ADORA2AADORA1NPC1RAB9A
SCHEMBL2671447 0.80 ADORA3 (0.44) ADORA3ADORA2AADORA1NPC1RAB9A
SCHEMBL7703870 0.77 ADORA2A (0.50) ADORA3ADORA2AADORA1NPC1RAB9A
SCHEMBL5492198 0.73 NPC1 (0.40) ADORA3ADORA2AADORA1NPC1RAB9A
SCHEMBL5360255 0.72 CYP3A4 (0.38) ADORA3SMN1; SMN2MAPTCYP2C19CYP1A2
SCHEMBL17973838 0.71 NPC1 (0.70) NPC1RAB9AALDH1A1SMN1; SMN2MAPT
SCHEMBL5363993 0.71 AR (0.46) MAPTKDM4EELANE
SCHEMBL16635591 0.70 NPC1 (0.55) ADORA3ADORA1NPC1RAB9AALDH1A1
SCHEMBL5906559 0.69 ADORA3 (0.47) ADORA3ADORA2AADORA1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007145349-A2 SUBSTITUTED PYRROLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-12-21 WO disclosed
WO-2007145349-A2 SUBSTITUTED PYRROLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-12-21 WO disclosed