Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 15/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22006739 | 0.81 | TLK2 (0.67) | TLK2NTRK1 | |
| SCHEMBL23369130 | 0.81 | TLK2 (0.57) | TLK2NTRK1 | |
| SCHEMBL30155003 | 0.81 | TLK2 (0.57) | TLK2NTRK1 | |
| SCHEMBL5365019 | 0.81 | TLK2 (0.67) | TLK2NTRK1 | |
| SCHEMBL5358327 | 0.81 | CDK2 (0.58) | CDK2SRCNTRK1KDR | |
| SCHEMBL5362175 | 0.80 | GSK3B (0.61) | CDK2SRCNTRK1KDR | |
| SCHEMBL5728095 | 0.80 | PDPK1 (0.73) | TLK2CDK2SRCNTRK1KDR | |
| SCHEMBL5363321 | 0.80 | PDPK1 (0.73) | TLK2CDK2SRCNTRK1KDR | |
| SCHEMBL30453667 | 0.79 | PDPK1 (0.64) | CDK2SRCNTRK1KDR | |
| SCHEMBL5369843 | 0.78 | SRC (0.59) | CDK2SRCNTRK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | TLK2 48/4885CDK2 256/4885SRC 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.