Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 4/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 4/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136300 | 0.83 | MAP3K7 (0.45) | MAP3K7TAB1MAP1LC3BPLK4SIRT1 | |
| SCHEMBL7139752 | 0.82 | MAP3K7 (0.39) | MAP3K7TAB1MAP1LC3BPLK4SIRT1 | |
| SCHEMBL5368618 | 0.81 | ERN1 (0.46) | MAP1LC3BPLK4SIRT1SIRT2SIRT3 | |
| SCHEMBL5362880 | 0.80 | PLK4 (0.57) | MAP3K7TAB1MAP1LC3BPLK4SIRT1 | |
| SCHEMBL7132034 | 0.80 | LRRK2 (0.50) | MAP1LC3BPLK4SIRT1SIRT2SIRT3 | |
| SCHEMBL5361530 | 0.79 | LRRK2 (0.49) | PLK4ALDH1A1MAPTLRRK2RET | |
| SCHEMBL5358356 | 0.79 | AR (0.52) | LRRK2MDM2 | |
| SCHEMBL7138980 | 0.79 | KMT2A (0.48) | MAP1LC3BPLK4SIRT1SIRT2SIRT3 | |
| SCHEMBL7134446 | 0.79 | NPC1 (0.43) | MAP3K7TAB1MAP1LC3BPLK4SIRT1 | |
| SCHEMBL5367274 | 0.78 | MEN1 (0.53) | PLK4KMT2ARAF1LRRK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MAP3K7 184/4885TAB1 756/4885MAP1LC3B 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.