Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 4/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137611 | 0.93 | MAP3K7 (0.47) | MAP3K7TAB1SIRT1SIRT2SIRT3 | |
| SCHEMBL7135224 | 0.87 | MAP3K7 (0.38) | MAP3K7TAB1SIRT1SIRT2SIRT3 | |
| SCHEMBL7132313 | 0.85 | GAA (0.45) | MAPTKMT2AMAPK1MEN1POLB | |
| SCHEMBL7132942 | 0.85 | PTP4A3 (0.45) | SIRT1MAP1LC3BMAPTKMT2APLK4 | |
| SCHEMBL7138173 | 0.85 | TDP1 (0.39) | SIRT1SIRT2SIRT3MAP1LC3BLRRK2 | |
| SCHEMBL7134752 | 0.84 | PLK4 (0.48) | MAP3K7TAB1SIRT1SIRT2SIRT3 | |
| SCHEMBL7138047 | 0.83 | LRRK2 (0.43) | SIRT1SIRT2SIRT3LRRK2MAPT | |
| SCHEMBL7131271 | 0.82 | ERN1 (0.38) | MAP3K7TAB1SIRT1SIRT2SIRT3 | |
| SCHEMBL5363330 | 0.82 | MAP3K7 (0.43) | MAP3K7TAB1SIRT1SIRT2SIRT3 | |
| SCHEMBL8193593 | 0.81 | PLK4 (0.51) | LRRK2MAPTKMT2AALDH1A1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |