Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F13A1 | P00488 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30427892 | 1.00 | F13A1 (0.50) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL26633682 | 0.94 | F13A1 (0.58) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL28259923 | 0.92 | F13A1 (0.61) | F13A1HDAC1HDAC8SLC6A3MEN1 | |
| SCHEMBL4716462 | 0.88 | NPSR1 (0.52) | HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL29009763 | 0.85 | NPSR1 (0.47) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL29010120 | 0.85 | F13A1 (0.44) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL27816726 | 0.85 | HDAC1 (0.47) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL28085944 | 0.84 | CA2 (0.40) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL29010123 | 0.81 | F13A1 (0.47) | F13A1HDAC1HDAC8FFAR1FFAR4 | |
| SCHEMBL6956901 | 0.81 | FFAR1 (0.50) | F13A1HDAC1HDAC8FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109824546-A | BOC- (R) -3- amino -4- (2,4,5- trifluorophenyl) butyric acid is condensed impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2019-05-31 | — | — | CN | claimed |
| CN-105254519-B | Synthesizing method of sitagliptin key intermediate | 常州吉恩药业有限公司 | 2017-05-17 | — | — | CN | claimed |
| CN-105254519-A | Synthesizing method of sitagliptin key intermediate | GENCHEM & GENPHARM CHANGZHOU CO LTD | 2016-01-20 | — | — | CN | claimed |
| CN-104130149-A | Recycling method of 3-(S)-aminobutyric acid derivative | ZHEJIANG CHANGMING PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | claimed |
| EP-4281439-A1 | SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES | The Scripps Research Institute (US) | 2023-11-29 | — | — | EP | disclosed |
| US-20230348378-A1 | SMALL MOLECULE ALBUMIN BINDERS | OREGON HEALTH & SCIENCE UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| WO-2023175492-A1 | NOVEL INTERMEDIATES AND ITS USE IN MANUFACTURING OF SITAGLIPTIN | HIKAL LIMITED (IN) | 2023-09-21 | — | — | WO | disclosed |
| CN-116209433-A | Small molecule albumin binding agents | 俄勒冈健康科学大学 | 2023-06-02 | — | — | CN | disclosed |
| WO-2023012819-A1 | RECOMBINANT TRANSAMINASE POLYPEPTIDES | QUANTUMZYME LLP (IN) | 2023-02-09 | — | — | WO | disclosed |
| WO-2022159955-A1 | SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-07-28 | — | — | WO | disclosed |
| WO-2022040607-A1 | SMALL MOLECULE ALBUMIN BINDERS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2022-02-24 | — | — | WO | disclosed |
| CN-109608348-A | A kind of synthetic method of (R) -3- t-butoxycarbonyl amino -4- (2,4,5- trifluorophenyl) butyric acid | 凯瑞斯德生化(苏州)有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-104130149-A | Recycling method of 3-(S)-aminobutyric acid derivative | ZHEJIANG CHANGMING PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | disclosed |
| CN-101781274-B | Acylated piperazine dipeptidyl peptidase IV inhibitor | KBP BIOSCIENCES CO LTD | 2013-01-02 | — | — | CN | disclosed |
| EP-2415754-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| WO-2011049344-A2 | METHOD OF PREPARING SITAGLIPTIN AND INTERMEDIATES USED THEREIN | HANMI HOLDINGS CO., LTD. (KR) | 2011-04-28 | — | — | WO | disclosed |
| EP-2292232-A1 | Beta-amino tetrahydroimidazo(1,2-A)pyrazines and tetrahydrotriazolo(4,3-A)pyrazines for use in the treatment of diabetes type II | Merck Sharp & Dohme Corp. (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |
| US-20100048570-A1 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | Kainos Medicine, Inc (KR) | 2010-02-25 | — | — | US | disclosed |
| US-20100048570-A1 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | Kainos Medicine, Inc (KR) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348378-A1 | SMALL MOLECULE ALBUMIN BINDERS | ALB, FABP1, FABP3 | F13A1 755/4885HDAC1 2839/4885HDAC8 3528/4885 |
| US-20100048570-A1 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | DPP4, DPP3, DPP7 | F13A1 4695/4885HDAC1 168/4885HDAC8 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.