Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 10/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | FCER2 | P06734 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 5/20 | 0.48 |
| ▸ | FYN | P06241 | 5/20 | 0.48 |
| ▸ | YES1 | P07947 | 5/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140809 | 0.83 | SRC (0.54) | PDPK1SRCKDRCDK2NTRK1 | |
| SCHEMBL5364795 | 0.82 | SRC (0.55) | PDPK1SRCKDRCDK2NTRK1 | |
| SCHEMBL5361859 | 0.82 | SRC (0.55) | PDPK1SRCKDRCDK2NTRK1 | |
| SCHEMBL5358922 | 0.81 | PDPK1 (0.63) | PDPK1NTRK1PAK4JAK3MAP4K1 | |
| SCHEMBL5369843 | 0.81 | SRC (0.59) | SRCKDRCDK2NTRK1FCER2 | |
| SCHEMBL24967151 | 0.81 | PDPK1 (0.74) | PDPK1NTRK1PAK4JAK3MAP4K1 | |
| SCHEMBL17674469 | 0.81 | PDPK1 (0.74) | PDPK1NTRK1PAK4JAK3MAP4K1 | |
| SCHEMBL17679355 | 0.81 | PDPK1 (0.74) | PDPK1NTRK1PAK4JAK3MAP4K1 | |
| SCHEMBL5363032 | 0.81 | SRC (0.54) | PDPK1SRCKDRCDK2NTRK1 | |
| SCHEMBL5359785 | 0.81 | SRC (0.54) | SRCKDRCDK2NTRK1FCER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | PDPK1 31/4885SRC 189/4885KDR 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.