Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | FCER2 | P06734 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | LCK | P06239 | 7/20 | 0.46 |
| ▸ | FYN | P06241 | 7/20 | 0.46 |
| ▸ | YES1 | P07947 | 7/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363032 | 0.84 | SRC (0.54) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL5363755 | 0.83 | PDPK1 (0.66) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL5364548 | 0.81 | KDR (0.59) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL7134796 | 0.81 | MOGAT2 (0.54) | NTRK1PDPK1 | |
| SCHEMBL5361859 | 0.81 | SRC (0.55) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL5364795 | 0.81 | SRC (0.55) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL5359785 | 0.80 | SRC (0.54) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL7132893 | 0.79 | SRC (0.55) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL5357946 | 0.79 | RET (0.64) | SRCCDK2NTRK1FCER2SYK | |
| SCHEMBL5368405 | 0.78 | SRC (0.52) | SRCCDK2NTRK1FCER2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |