Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.68 |
| ▸ | CA1 | P00915 | 5/20 | 0.68 |
| ▸ | CA2 | P00918 | 5/20 | 0.68 |
| ▸ | CA7 | P43166 | 5/20 | 0.68 |
| ▸ | CA9 | Q16790 | 5/20 | 0.68 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.68 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | ESRRA | P11474 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23484283 | 0.86 | CA12 (0.66) | CA12CA1CA2CA7CA9 | |
| SCHEMBL12305564 | 0.85 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7940256 | 0.84 | HSP90AA1 (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL18016984 | 0.83 | ESR1 (0.59) | HSP90AA1HSP90AB1ESR1LMNACYP1A2 | |
| SCHEMBL11404522 | 0.83 | ESR1 (0.59) | HSP90AA1HSP90AB1ESR1LMNACYP1A2 | |
| SCHEMBL19182178 | 0.83 | ESR1 (0.59) | HSP90AA1HSP90AB1ESR1LMNACYP1A2 | |
| SCHEMBL18016986 | 0.83 | ESR1 (0.59) | HSP90AA1HSP90AB1ESR1LMNACYP1A2 | |
| SCHEMBL19182177 | 0.83 | ESR1 (0.59) | HSP90AA1HSP90AB1ESR1LMNACYP1A2 | |
| SCHEMBL12305545 | 0.83 | ALDH1A1 (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL19317256 | 0.82 | CA12 (0.56) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205409-B2 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2007-04-17 | — | — | US | disclosed |
| US-20050131019-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBVIE INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005023762-A1 | PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131019-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | DPP4, DPP3, DPP7 | CA12 2859/4885CA1 2745/4885CA2 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.