⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135658 | 0.83 | — | — | |
| SCHEMBL5369219 | 0.75 | MAPT (0.42) | — | |
| SCHEMBL5362737 | 0.68 | MAPT (0.37) | — | |
| SCHEMBL7138244 | 0.67 | CCNE1 (0.34) | — | |
| SCHEMBL5377025 | 0.64 | RET (0.54) | — | |
| SCHEMBL7134014 | 0.64 | RET (0.48) | — | |
| SCHEMBL5364403 | 0.64 | KMT2A (0.56) | — | |
| SCHEMBL7137544 | 0.64 | LRRK2 (0.49) | — | |
| SCHEMBL5367431 | 0.64 | RET (0.55) | — | |
| SCHEMBL7139982 | 0.64 | NPC1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |