Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134022 | 0.89 | LRRK2 (0.48) | RETERBB2MDM2LRRK2 | |
| SCHEMBL5377025 | 0.89 | RET (0.54) | RETMAPTHPGDPIM1PDGFRB | |
| SCHEMBL7134871 | 0.87 | RET (0.44) | RETMAPTHPGDPDGFRBERBB2 | |
| SCHEMBL5367625 | 0.87 | METAP1 (0.56) | RETMAPTHPGDPIM1PIM2 | |
| SCHEMBL5358699 | 0.87 | GSK3B (0.45) | RETMAPTHPGDPDGFRBERBB2 | |
| SCHEMBL7137405 | 0.87 | IGF1R (0.45) | RETMAPTPIM1PIM2PDGFRB | |
| SCHEMBL7136100 | 0.87 | RET (0.67) | RETMAPTHPGDPIM1PDGFRB | |
| SCHEMBL7132867 | 0.87 | PDGFRB (0.55) | RETPIM1PDGFRBERBB2MEN1 | |
| SCHEMBL7137036 | 0.84 | METAP1 (0.56) | RETMAPTMEN1KMT2AKDM4E | |
| SCHEMBL7136206 | 0.83 | RET (0.50) | RETMAPTHPGDPDGFRBERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |