Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744015 | 0.98 | MAPT (0.47) | MAPTALDH1A1GAAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL5410295 | 0.94 | MAPT (0.49) | MAPTALDH1A1GAAKDM4EHTT | |
| SCHEMBL6744328 | 0.92 | MAPT (0.50) | MAPTALDH1A1GAAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL5351935 | 0.91 | CHRNA10 (0.52) | MAPTALDH1A1GAAKDM4EHTT | |
| SCHEMBL6745286 | 0.89 | CHRNA10 (0.54) | MAPTALDH1A1GAAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL5352676 | 0.86 | CHRNA10 (0.48) | MAPTALDH1A1GAAKDM4EHTT | |
| SCHEMBL6742112 | 0.84 | CHRNA10 (0.49) | MAPTALDH1A1GAAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL5349721 | 0.84 | MAPT (0.46) | MAPTALDH1A1GAAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL5358867 | 0.83 | MAPT (0.46) | MAPTALDH1A1GAAKDM4EHTT | |
| SCHEMBL5351218 | 0.82 | MAPT (0.47) | MAPTALDH1A1GAAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186277-B2 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | L'OREAL SA (FR) | 2007-03-06 | — | — | US | disclosed |