Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020442 | 0.81 | KDM4E (0.52) | KDM4EGPR3ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL159416 | 0.74 | KDM4E (0.59) | KDM4EGPR3ALDH1A1MAPTMEN1 | |
| SCHEMBL31684807 | 0.74 | KDM4E (0.59) | KDM4EGPR3ALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL9110426 | 0.72 | KDM4E (0.57) | KDM4EGPR3ALDH1A1MAPTMEN1 | |
| SCHEMBL646163 | 0.70 | CA1 (0.52) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL9038627 | 0.69 | KDM4E (0.59) | KDM4EGPR3ALDH1A1HTTMAPT | |
| SCHEMBL25487988 | 0.68 | KDM4E (0.54) | KDM4EALDH1A1CYP11B2LRRK2HTT | |
| SCHEMBL1773061 | 0.68 | KDM4E (0.46) | KDM4EGPR3ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL29780666 | 0.68 | CYP3A4 (0.58) | KDM4EGPR3ALDH1A1HTTMAPT | |
| SCHEMBL14311585 | 0.68 | KDM4E (0.48) | KDM4EGPR3ALDH1A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226924-B2 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2007-06-05 | — | — | US | disclosed |
| US-20030220322-A1 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220322-A1 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | DPYD, P2RX5, P2RX2 | KDM4E 3131/4885GPR3 856/4885ALDH1A1 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.