Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.58 |
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 8/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371356 | 0.84 | NR1H4 (0.80) | KDM4ENR1H4BACE1BRD4ATM | |
| SCHEMBL5369551 | 0.79 | KDM4E (0.75) | KDM4EMAPTHSD17B10NR1H4BACE1 | |
| SCHEMBL5372147 | 0.78 | GAA (0.66) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL15332882 | 0.70 | KDM4E (0.59) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL5421593 | 0.70 | NR1H4 (0.81) | KDM4EALDH1A1NR1H4GAARAB9A | |
| SCHEMBL1609483 | 0.69 | KDM4E (0.52) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL5370506 | 0.68 | GAA (0.80) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL1052939 | 0.67 | PIK3CG (0.86) | — | |
| SCHEMBL12738233 | 0.67 | ALDH1A1 (0.53) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL1946565 | 0.67 | ALDH1A1 (0.56) | KDM4EMAPTALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067711-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | claimed |
| WO-2007067711-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |