Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359225 | 0.81 | CFTR (0.52) | CFTRTSHRMEN1KMT2ACTSD | |
| SCHEMBL5366161 | 0.80 | CFTR (0.54) | CFTRTRPV1TSHRPDK1 | |
| SCHEMBL14134465 | 0.72 | SMN1; SMN2 (0.53) | TSHRMEN1KMT2ACTSD | |
| SCHEMBL14093517 | 0.69 | KDM4E (0.45) | MEN1KMT2A | |
| SCHEMBL5361213 | 0.68 | LMNA (0.41) | CFTRMEN1KMT2ACTSD | |
| SCHEMBL3997345 | 0.68 | NCEH1 (0.58) | MEN1KMT2ACTSD | |
| SCHEMBL14093515 | 0.67 | F2 (0.49) | — | |
| SCHEMBL5361690 | 0.67 | TSHR (0.42) | TSHRMEN1KMT2APDK1 | |
| SCHEMBL11849935 | 0.66 | CNR2 (0.52) | MEN1KMT2ACTSD | |
| SCHEMBL31484246 | 0.66 | MAPT (0.46) | MEN1KMT2ACTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291621-B2 | Substituted biaryl amides C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-11-06 | — | — | US | claimed |
| US-7291621-B2 | Substituted biaryl amides C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291621-B2 | Substituted biaryl amides C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |