Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365803 | 0.90 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL3241870 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL194989 | 0.82 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL30062014 | 0.82 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL5371049 | 0.76 | KMT2A (0.49) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL5365676 | 0.74 | HTT (0.42) | ALDH1A1MAPTLMNAHTTKDM4E | |
| SCHEMBL3240065 | 0.74 | ALDH1A1 (0.38) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL1459233 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNANPC1HTT | |
| SCHEMBL3242146 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPTHIF1AKMT2A | |
| SCHEMBL1898380 | 0.74 | SMN1; SMN2 (0.57) | ALDH1A1MAPTNPC1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300950-B2 | Pyrazole derivatives, their preparation and their use in pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2007-11-27 | — | — | US | disclosed |
| EP-1608975-A1 | SENSOR FOR DETECTING AN ANALYTE USING SILVER NANOPARTICLES | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2005-12-28 | — | — | EP | disclosed |
| US-20050176799-A1 | Pyrazole derivatives, their preparation and their use in pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH. | 2005-08-11 | — | — | US | disclosed |
| US-6897232-B2 | Pyrazole derivatives, their preparation and their use in pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-05-24 | — | — | US | disclosed |
| WO-2004086044-A1 | SENSOR FOR DETECTING AN ANALYTE USING SILVER NANOPARTICLES | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2004-10-07 | — | — | WO | disclosed |
| US-20030105336-A1 | Pyrazole derivatives, their preparation and their use in pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH | 2003-06-05 | — | — | US | disclosed |
| US-6162819-A | Pyrazole derivatives, their preparation and their use in pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-19 | — | — | US | disclosed |
| CN-1214339-A | Pyrazole derivatives, their preparation and their use in pharmaceuticals | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-04-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176799-A1 | Pyrazole derivatives, their preparation and their use in pharmaceuticals | PDE3A, PDE3B, PDE5A | ALDH1A1 977/4885MAPT 4369/4885LMNA 409/4885 |
| US-20030105336-A1 | Pyrazole derivatives, their preparation and their use in pharmaceuticals | PDE3B, PDE3A, PDE5A | ALDH1A1 750/4885MAPT 4507/4885LMNA 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.