Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 4/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369667 | 0.83 | HDAC3 (0.65) | FLT3PDGFRBFGFR1ALKABL1 | |
| SCHEMBL5359118 | 0.80 | FLT3 (0.68) | FLT3PDGFRBFGFR1ALKABL1 | |
| SCHEMBL5365979 | 0.79 | FLT3 (0.66) | FLT3PDGFRBFGFR1ALKABL1 | |
| SCHEMBL5357950 | 0.79 | PAK1 (0.46) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5362266 | 0.78 | HDAC3 (0.46) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5363278 | 0.77 | PDGFRB (0.68) | FLT3PDGFRBFGFR1ALKABL1 | |
| SCHEMBL5373331 | 0.77 | TLK2 (0.67) | FLT3PDGFRBAURKBAURKAAURKC | |
| SCHEMBL5384496 | 0.77 | FLT3 (0.62) | FLT3PDGFRBFGFR1ALKABL1 | |
| SCHEMBL19255670 | 0.76 | PDGFRB (0.77) | FLT3PDGFRBFGFR1ALKABL1 | |
| SCHEMBL5373629 | 0.75 | PDGFRB (0.76) | FLT3PDGFRBFGFR1ALKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |