Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.59 |
| ▸ | AKT2 | P31751 | 1/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429175 | 0.83 | PAK1 (0.68) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL8429168 | 0.83 | PAK1 (0.68) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL5369667 | 0.82 | HDAC3 (0.65) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL5357950 | 0.82 | PAK1 (0.46) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL5362266 | 0.81 | HDAC3 (0.46) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL22682 | 0.79 | PDGFRB (0.85) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL22683 | 0.79 | PDGFRB (0.85) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL21115 | 0.79 | HDAC3 (1.00) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL21116 | 0.79 | HDAC3 (1.00) | TLK2HDAC3HDAC1HDAC2PDGFRB | |
| SCHEMBL12473992 | 0.78 | PDGFRB (0.85) | TLK2HDAC3HDAC1HDAC2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-0929520-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998007695-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1998-02-26 | — | — | WO | disclosed |