Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 5/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367282 | 0.85 | KMT2A (0.60) | ALDH1A1MAPTRPS6KA3MEN1KMT2A | |
| SCHEMBL5373671 | 0.83 | GSK3B (0.44) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL5363472 | 0.81 | PTPN1 (0.48) | ALDH1A1MAPTRPS6KA3MEN1KMT2A | |
| SCHEMBL5369248 | 0.81 | RET (0.65) | ALDH1A1MAPTRPS6KA3MEN1KMT2A | |
| SCHEMBL5367384 | 0.80 | RPS6KA3 (0.43) | ALDH1A1MAPTRPS6KA3MEN1KMT2A | |
| SCHEMBL6830072 | 0.80 | RPS6KA3 (0.62) | ALDH1A1MAPTRPS6KA3MEN1KMT2A | |
| SCHEMBL6855418 | 0.80 | RPS6KA3 (0.62) | ALDH1A1MAPTRPS6KA3MEN1KMT2A | |
| SCHEMBL7139419 | 0.79 | MEN1 (0.67) | MAPTRPS6KA3MEN1KMT2ALMNA | |
| SCHEMBL7137564 | 0.79 | PSEN1 (0.52) | MAPTMEN1KMT2ARETLRRK2 | |
| SCHEMBL7134047 | 0.79 | PTPN1 (0.48) | ALDH1A1RPS6KA3MEN1KMT2ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | ALDH1A1 2044/4885MAPT 3048/4885RPS6KA3 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.