Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370123 | 0.79 | MEN1 (0.44) | MAPTKMT2AAPPALDH1A1SNCA | |
| SCHEMBL5358662 | 0.78 | KDR (0.66) | MAPTKMT2ARECQLNPSR1TDP1 | |
| SCHEMBL6001532 | 0.77 | LRRK2 (0.58) | EGFRRETERBB2PDGFRBLRRK2 | |
| SCHEMBL6001533 | 0.77 | LRRK2 (0.58) | EGFRRETERBB2PDGFRBLRRK2 | |
| SCHEMBL5363527 | 0.77 | PDPK1 (0.65) | PDPK1RETJAK3PDGFRBLRRK2 | |
| SCHEMBL14519109 | 0.77 | TLK2 (0.57) | KMT2APDPK1JAK3PDGFRBKDR | |
| SCHEMBL5359077 | 0.77 | EGFR (0.47) | MAPTKMT2AALDH1A1THRBHPGD | |
| SCHEMBL5364974 | 0.75 | PDPK1 (0.46) | MAPTKMT2AALDH1A1THRBHPGD | |
| SCHEMBL5367195 | 0.74 | PDPK1 (0.57) | MAPTKMT2AALDH1A1THRBHPGD | |
| SCHEMBL5368073 | 0.74 | PDPK1 (0.61) | PDPK1JAK3TLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |