Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358662 | 0.79 | KDR (0.66) | MEN1MAPTKMT2ANPC1JAK3 | |
| SCHEMBL5367000 | 0.79 | MAPT (0.43) | MEN1MAPTKMT2AALDH1A1JAK3 | |
| SCHEMBL6297823 | 0.78 | LRRK2 (0.60) | LRRK2RETPDGFRBEGFRERBB2 | |
| SCHEMBL6297819 | 0.78 | LRRK2 (0.60) | LRRK2RETPDGFRBEGFRERBB2 | |
| SCHEMBL5358278 | 0.77 | MEN1 (0.46) | MEN1MAPTKMT2ANPC1ALDH1A1 | |
| SCHEMBL5363527 | 0.76 | PDPK1 (0.65) | JAK3KDRPDPK1LRRK2RET | |
| SCHEMBL5359359 | 0.76 | TLK2 (0.47) | MEN1MAPTKMT2ANPC1ALDH1A1 | |
| SCHEMBL5361719 | 0.75 | PDPK1 (0.58) | KDRPDPK1PDGFRBEGFR | |
| SCHEMBL5364110 | 0.75 | PDPK1 (0.56) | MEN1MAPTKMT2ANPC1ALDH1A1 | |
| SCHEMBL5727507 | 0.75 | KDR (0.71) | MEN1MAPTKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |