Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PAICS | P22234 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.31 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084691 | 0.86 | KCNH2 (0.40) | KCNH2HRH3ABL1L3MBTL1KDM4E | |
| SCHEMBL5334701 | 0.83 | IGF1R (0.47) | PLAURIGF1RCYP3A4MAOAMAOB | |
| SCHEMBL5142055 | 0.83 | TNK2 (0.35) | PLAURHRH3KDM4EPRMT5ALDH1A1 | |
| SCHEMBL5141251 | 0.83 | PLAUR (0.44) | PLAURCYP3A4KCNH2HRH3L3MBTL1 | |
| SCHEMBL29152983 | 0.73 | KMT2A (0.47) | PLAURDRD2DRD4DRD3HPGD | |
| SCHEMBL396337 | 0.72 | PIK3CD (0.56) | ABL1 | |
| SCHEMBL400110 | 0.71 | SRC (0.63) | IGF1RCYP3A4ABL1L3MBTL1KDM4E | |
| SCHEMBL27678734 | 0.71 | IGF1R (0.35) | IGF1RCYP3A4MAOAMAOBKCNH2 | |
| SCHEMBL402699 | 0.70 | IGF1R (0.62) | IGF1RCYP3A4 | |
| SCHEMBL401087 | 0.69 | IGF1R (0.75) | IGF1RCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |