Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.47 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | INSRR | P14616 | 1/20 | 0.37 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367129 | 0.83 | PLAUR (0.40) | IGF1RCYP3A4PLAURKDM4EALDH1A1 | |
| SCHEMBL29152983 | 0.79 | KMT2A (0.47) | PLAURNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5161210 | 0.73 | AHR (0.39) | IGF1RPLAURNPC1RAB9AKDM4E | |
| SCHEMBL10039876 | 0.72 | RAB9A (0.55) | IGF1RCYP3A4NPC1RAB9AKDM4E | |
| SCHEMBL4503250 | 0.71 | PLAUR (0.55) | CYP3A4PLAURINSRKMT2A | |
| SCHEMBL17239582 | 0.71 | KMT2A (0.44) | CYP3A4PLAURMAPK1NPC1RAB9A | |
| SCHEMBL3418909 | 0.69 | KEAP1 (0.51) | CYP3A4NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5084691 | 0.69 | KCNH2 (0.40) | MAPK1KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24453776 | 0.69 | RAB9A (0.47) | IGF1RCYP3A4NPC1RAB9AKDM4E | |
| SCHEMBL400556 | 0.69 | PIK3CD (0.70) | KDRLCKLYNEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |