Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | MAT2A | P31153 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5393887 | 0.86 | TRPA1 (0.47) | MAPK14TRPA1MAT2AKDM4EHSD17B10 | |
| SCHEMBL5385676 | 0.85 | MAPK14 (0.50) | MAPK14TRPA1KDM4ETDP1 | |
| SCHEMBL5364802 | 0.83 | MAPK14 (0.66) | MAPK14KDM4ENR3C1PGRCSNK1E | |
| SCHEMBL6594341 | 0.83 | MAPK14 (0.45) | MAPK14KDM4E | |
| SCHEMBL5373880 | 0.82 | MAPK14 (0.44) | MAPK14TRPA1MAT2APTPN1ICMT | |
| SCHEMBL5382399 | 0.82 | MAPK14 (0.59) | MAPK14CSNK1ECSNK1D | |
| SCHEMBL5384291 | 0.80 | MAPK14 (0.46) | MAPK14TRPA1NR3C1ICMT | |
| SCHEMBL5370450 | 0.78 | TRPA1 (0.44) | MAPK14TRPA1MAT2ACSNK1ECSNK1D | |
| SCHEMBL5385623 | 0.77 | MAPK14 (0.51) | MAPK14MAT2AKDM4EPTPN1CSNK1E | |
| SCHEMBL5366953 | 0.77 | MAPK14 (0.54) | MAPK14PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223772-B1 | Pyrazolopyridine derivatives as selective cox-2 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1127058-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2004-09-01 | — | — | EP | disclosed |
| EP-1157025-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2004-03-10 | — | — | EP | disclosed |
| US-6498166-B1 | POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2; TREATING PAIN, FEVER AND INFLAMMATION | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1157025-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2001-11-28 | — | — | EP | disclosed |
| EP-1127058-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000052008-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000026216-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-05-11 | — | — | WO | disclosed |