Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344867 | 0.92 | TLR7 (0.39) | TLR7ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5351611 | 0.85 | TLR7 (0.37) | TLR7ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL14344550 | 0.80 | TLR7 (0.37) | TLR7ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5357675 | 0.76 | TLR7 (0.36) | TLR7MEN1KMT2ATLR8 | |
| SCHEMBL5353039 | 0.76 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL5361903 | 0.76 | PDE10A (0.45) | TLR7PDE10A | |
| SCHEMBL5364985 | 0.74 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL8113805 | 0.70 | TLR7 (0.39) | TLR7ALDH1A1MEN1KMT2ATLR8 | |
| SCHEMBL5118920 | 0.68 | TLR7 (0.42) | TLR7TLR8 | |
| SCHEMBL3355061 | 0.68 | TLR7 (0.49) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143526-A2 | SUBSTITUTED TETRAHYDROIMIDAZONAPHTHYRIDINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143526-A2 | SUBSTITUTED TETRAHYDROIMIDAZONAPHTHYRIDINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-12-13 | — | — | WO | disclosed |