SCHEMBL5369655

SCHEMBL5369655

NCCCCC(=O)C(N)CCC(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.58
NFKB1 P19838 2/20 0.58
LMNA P02545 3/20 0.56
BLM P54132 2/20 0.56
NPSR1 Q6W5P4 2/20 0.56
THRB P10828 2/20 0.56
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
ALDH1A1 P00352 1/20 0.56
PLG P00747 1/20 0.56
ALOX15 P16050 1/20 0.56
SLC6A2 P23975 1/20 0.56
RECQL P46063 1/20 0.56
SLC6A3 Q01959 1/20 0.56
GSR P00390 2/20 0.54
CYP1A2 P05177 2/20 0.54
GRM8 O00222 1/20 0.54
GRM6 O15303 1/20 0.54
GRIN2D O15399 1/20 0.54
GRIN3B O60391 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2750074 0.94 LMNA (0.56) CYP2D6NFKB1LMNABLMNPSR1
SCHEMBL3959872 0.89 LMNA (0.63) CYP2D6NFKB1LMNABLMNPSR1
SCHEMBL29622843 0.89 LMNA (0.63) CYP2D6NFKB1LMNABLMNPSR1
SCHEMBL29622881 0.89 LMNA (0.63) CYP2D6NFKB1LMNABLMNPSR1
SCHEMBL30914234 0.88 GRM8 (0.58) CYP2D6NFKB1LMNATHRBKMT2A
SCHEMBL15569584 0.88 GRM8 (0.58) CYP2D6NFKB1LMNATHRBKMT2A
SCHEMBL31088659 0.88 GRM8 (0.58) CYP2D6NFKB1LMNATHRBKMT2A
SCHEMBL31171172 0.88 GRM8 (0.58) CYP2D6NFKB1LMNATHRBKMT2A
SCHEMBL16950119 0.85 CYP1A2 (0.60) CYP2D6NFKB1LMNABLMNPSR1
Glutamic Acid SCHEMBL15300086 0.84 GSR (0.72) CYP2D6NFKB1LMNABLMNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220054590-A1 PROTOXIN-II VARIANTS AND METHODS OF USE THEREOF JANSSEN BIOTECH, INC. 2022-02-24 US claimed
US-11083776-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2021-08-10 US claimed
US-20200054712-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2020-02-20 US claimed
US-10463714-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2019-11-05 US claimed
EP-3277304-A1 PROTOXIN-II VARIANTS AND METHODS OF USE Janssen Biotech, Inc. (US) 2018-02-07 EP claimed
WO-2016161100-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. (US) 2016-10-06 WO claimed
US-20160287666-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2016-10-06 US claimed
US-7279149-B2 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2007-10-09 US claimed
WO-2005042005-A1 AMINO ACID COMPOSITION WITH INCREASED BLOOD BRAIN BARRIER PERMEABILITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2005-05-12 WO claimed
US-20050095201-A1 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2005-05-05 US claimed
US-20220054590-A1 PROTOXIN-II VARIANTS AND METHODS OF USE THEREOF JANSSEN BIOTECH, INC. 2022-02-24 US disclosed
US-20210363204-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2021-11-25 US disclosed
US-11083776-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2021-08-10 US disclosed
EP-3277304-B1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH INC (US) 2021-08-04 EP disclosed
US-20200054712-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2020-02-20 US disclosed
US-7279149-B2 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2007-10-09 US disclosed
WO-2005042005-A1 AMINO ACID COMPOSITION WITH INCREASED BLOOD BRAIN BARRIER PERMEABILITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2005-05-12 WO disclosed
WO-2005042005-A1 AMINO ACID COMPOSITION WITH INCREASED BLOOD BRAIN BARRIER PERMEABILITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2005-05-12 WO disclosed
US-20050095201-A1 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2005-05-05 US disclosed
US-20050095201-A1 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2005-05-05 US disclosed