Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 8/20 | 0.49 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | ARAF | P10398 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5357751 | 0.94 | MOGAT2 (0.55) | MOGAT2RAF1MGAT2ERBB2LRRK2 | |
| SCHEMBL5370195 | 0.91 | MOGAT2 (0.51) | MOGAT2RAF1MGAT2ERBB2LRRK2 | |
| SCHEMBL5361605 | 0.90 | MAP1LC3B (0.57) | MOGAT2RAF1MGAT2LRRK2EGFR | |
| SCHEMBL5362802 | 0.89 | MOGAT2 (0.49) | MOGAT2MGAT2ERBB2LRRK2EGFR | |
| SCHEMBL5365889 | 0.89 | ERBB2 (0.63) | MOGAT2RAF1MGAT2ERBB2LRRK2 | |
| SCHEMBL5367175 | 0.87 | MOGAT2 (0.53) | MOGAT2MGAT2ERBB2LRRK2EGFR | |
| SCHEMBL5362515 | 0.86 | MOGAT2 (0.53) | MOGAT2MGAT2ERBB2EGFRIGF1R | |
| SCHEMBL5367172 | 0.86 | ERBB2 (0.54) | MOGAT2MGAT2ERBB2LRRK2EGFR | |
| SCHEMBL5377169 | 0.85 | LRRK2 (0.57) | MOGAT2RAF1MGAT2LRRK2EGFR | |
| SCHEMBL5366394 | 0.85 | MOGAT2 (0.56) | MOGAT2RAF1MGAT2LRRK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MOGAT2 1159/4885RAF1 245/4885MGAT2 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.