Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369864 | 1.00 | BACE1 (0.43) | BACE1BACE2CTSD | |
| SCHEMBL6819577 | 0.87 | BACE1 (0.47) | BACE1BACE2CTSD | |
| SCHEMBL5376054 | 0.81 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL6807775 | 0.81 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL6807777 | 0.81 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL7613103 | 0.78 | BACE1 (0.60) | BACE1BACE2CTSD | |
| SCHEMBL7608367 | 0.77 | BACE1 (0.54) | BACE1BACE2CTSD | |
| SCHEMBL7641045 | 0.74 | BACE1 (0.42) | BACE1BACE2CTSD | |
| SCHEMBL5376143 | 0.71 | BACE1 (0.66) | BACE1BACE2CTSD | |
| SCHEMBL7063529 | 0.71 | BACE1 (0.66) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262208-B2 | Hydroxypropyl amides for the treatment of Alzheimer's disease | ELAN PHARMACEUTICALS, INC. (US) | 2007-08-28 | — | — | US | disclosed |