Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382745 | 0.90 | NR1H3 (0.36) | KDM4ERECQLTDP1LMNAESR1 | |
| SCHEMBL5369504 | 0.85 | KDM4E (0.36) | KDM4ERECQLTDP1ADORA2AADORA2B | |
| SCHEMBL23399267 | 0.84 | ADORA2A (0.33) | ADORA2AADORA2BESR1 | |
| SCHEMBL13741415 | 0.75 | ADORA2A (0.46) | ADORA2AADORA2BESR1 | |
| SCHEMBL5393593 | 0.75 | POLB (0.36) | KDM4ERECQLLMNA | |
| SCHEMBL23401528 | 0.74 | NR1H3 (0.36) | ESR1 | |
| SCHEMBL5377985 | 0.73 | — | — | |
| SCHEMBL23402950 | 0.72 | GAA (0.41) | ADORA2AADORA2BESR1 | |
| SCHEMBL23398975 | 0.70 | ADORA2A (0.34) | ADORA2AADORA2BESR1 | |
| SCHEMBL15334767 | 0.69 | KDM4E (0.37) | KDM4ERECQLTDP1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1541561-B1 | PYRAZOLE DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF | IHARA CHEMICAL IND CO (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-20070249844-A1 | Pyrazole derivatives and process for the production thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-10-25 | — | — | US | disclosed |
| US-7256298-B2 | Pyrazole derivatives and process for the production thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-08-14 | — | — | US | disclosed |
| US-20050215797-A1 | Pyrazole derivatives and process for the production thereof | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2005-09-29 | — | — | US | disclosed |
| EP-1541561-A1 | PYRAZOLE DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249844-A1 | Pyrazole derivatives and process for the production thereof | CBR3, CYP4Z1, CYP4F3 | KDM4E 3841/4885RECQL 3250/4885TDP1 3951/4885 |
| US-20050215797-A1 | Pyrazole derivatives and process for the production thereof | CBR3, CYP4Z1, CYP4F3 | KDM4E 3841/4885RECQL 3250/4885TDP1 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.