Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.49 |
| ▸ | CHRNG | P07510 | 2/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | CHRND | Q07001 | 2/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28529322 | 0.84 | PARP1 (0.52) | GSK3BPARP1SLC6A2SLC6A3CHRNA1 | |
| SCHEMBL3362673 | 0.82 | PARP1 (0.57) | GSK3BPARP1SLC6A2SLC6A3CHRNA1 | |
| SCHEMBL10898106 | 0.80 | PARP1 (0.55) | GSK3BPARP1SLC6A2SLC6A3CHRNA1 | |
| SCHEMBL28473881 | 0.80 | PARP1 (0.55) | GSK3BPARP1SLC6A2SLC6A3CHRNA1 | |
| SCHEMBL29848174 | 0.79 | SLC6A2 (0.59) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL633225 | 0.79 | SLC6A2 (0.59) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL8639727 | 0.79 | PARP1 (0.53) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL10501628 | 0.78 | HPGD (0.51) | PARP1SMN1; SMN2CTSVCTSLCTSB | |
| SCHEMBL19926137 | 0.78 | KMT2A (0.50) | PARP1SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL395491 | 0.77 | MDM2 (0.48) | GSK3BPARP1CYP2C19HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186829-B1 | Aryl-substituted heterocyclic enaminones | BAYER AKTIENGESELLSCHAFT (DE) | 2007-03-06 | — | — | US | disclosed |
| US-7186829-B1 | Aryl-substituted heterocyclic enaminones | BAYER AKTIENGESELLSCHAFT (DE) | 2007-03-06 | — | — | US | disclosed |
| US-7186829-B1 | Aryl-substituted heterocyclic enaminones | BAYER AKTIENGESELLSCHAFT (DE) | 2007-03-06 | — | — | US | disclosed |
| US-7049271-B2 | Phenyl-substituted 2-enamino-ketonitriles | BAYER AKTIENGESELLSCHAFT (DE) | 2006-05-23 | — | — | US | disclosed |
| US-20060100106-A1 | Phenyl-substituted 2-enamino-ketonitriles | FISCHER REINER | 2006-05-11 | — | — | US | disclosed |
| US-20060069253-A1 | Aryl-substituted heterocyclic enaminones | FISCHER REINER | 2006-03-30 | — | — | US | disclosed |
| EP-1129071-B1 | PHENYL-SUBSTITUTED CYCLIC ENAMINONES | BAYER CROPSCIENCE AG (DE) | 2005-10-26 | — | — | EP | disclosed |
| US-20030220196-A1 | Phenyl-substituted-2enamino-keto nitriles | BAYER AKTIENGESELLSCHAFT (DE) | 2003-11-27 | — | — | US | disclosed |
| US-20030130125-A1 | Phenyl-substituted cyclic enaminones | FISCHER REINER (DE) | 2003-07-10 | — | — | US | disclosed |
| EP-1286956-A1 | PHENYL-SUBSTITUTED 2-ENAMINO-KETO NITRILES | Bayer CropScience AG (DE) | 2003-03-05 | — | — | EP | disclosed |
| EP-1259496-A1 | (HETERO)ARYL-SUBSTITUTED HETEROCYCLIC ENAMINONES, PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES, ACARICIDES AND INSECTICIDES | Bayer CropScience AG (DE) | 2002-11-27 | — | — | EP | disclosed |
| US-6455472-B1 | HERBICIDES, ACARICIDES, NEMATICIDES AND INSECTICIDES FOR CROPS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-24 | — | — | US | disclosed |
| WO-2001085673-A1 | PHENYL-SUBSTITUTED 2-ENAMINO-KETO NITRILES | BAYER CROPSCIENCE AG (DE) | 2001-11-15 | — | — | WO | disclosed |
| EP-1129071-A1 | PHENYL-SUBSTITUTED CYCLIC ENAMINONES | Bayer Aktiengesellschaft (DE) | 2001-09-05 | — | — | EP | disclosed |
| WO-2001040202-A1 | (HETERO)ARYL-SUBSTITUTED HETEROCYCLIC ENAMINONES, PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES, ACARICIDES AND INSECTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-06-07 | — | — | WO | disclosed |
| WO-2000027812-A1 | PHENYL-SUBSTITUTED CYCLIC ENAMINONES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130125-A1 | Phenyl-substituted cyclic enaminones | DDT, CYP19A1, KCNA1 | GSK3B 1661/4885PARP1 798/4885SLC6A2 3050/4885 |
| US-20060069253-A1 | Aryl-substituted heterocyclic enaminones | DDT, NPY4R, NPY5R | GSK3B 3876/4885PARP1 4630/4885SLC6A2 2803/4885 |
| US-20060100106-A1 | Phenyl-substituted 2-enamino-ketonitriles | AR, KCNK4, KCNA1 | GSK3B 1570/4885PARP1 2073/4885SLC6A2 2606/4885 |
| US-20030220196-A1 | Phenyl-substituted-2enamino-keto nitriles | CYP1A1, CYP4X1, KCNK4 | GSK3B 1964/4885PARP1 1858/4885SLC6A2 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.