Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351255 | 1.00 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5358219 | 0.90 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5362296 | 0.86 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5349673 | 0.86 | MAPK1 (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5355045 | 0.85 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5354647 | 0.85 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5355047 | 0.85 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7624779 | 0.85 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5755229 | 0.84 | PDE4B (0.67) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5360475 | 0.84 | PDE4B (0.67) | PDE4APDE4BPDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |
| US-20060074123-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2006-04-06 | — | — | US | disclosed |
| US-6998416-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2006-02-14 | — | — | US | disclosed |
| US-20040152754-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (A WASHINGTON CORPORATION) | 2004-08-05 | — | — | US | disclosed |
| US-6716871-B2 | OBESITY; INFLAMMATORY DISEASES, DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES, CENTRAL NERVOUS SYSTEM DISORDERS; 3-HYDROXYALKYL-4-DIALKOXYPHENYL-SUBSTITUTED PYRROLIDINES | ICOS CORPORATION | 2004-04-06 | — | — | US | disclosed |
| US-20040023945-A1 | CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION | 2004-02-05 | — | — | US | disclosed |
| US-6680336-B2 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASES INHIBITORS; ANTIINFLAMMATORY AGENTS; 2,3-DIOXY-4-PYRROLE SUBSTITUTED PHENYL DERIVATIVES | ICOS CORPORATION | 2004-01-20 | — | — | US | disclosed |
| US-20020169196-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION | 2002-11-14 | — | — | US | disclosed |
| US-6458787-B1 | NOVEL PYRROLIDINE COMPOUNDS THAT ARE POTENT AND SELECTIVE INHIBITORS OF PDE4, AS WELL AS METHODS OF MAKING THE SAME, ARE DISCLOSED. USE OF THE COMPOUNDS IN THE TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED | ICOS CORPORATION | 2002-10-01 | — | — | US | disclosed |
| US-6455562-B1 | TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES, AS WELL AS CENTRAL NERVOUS SYSTEM DISORDERS | ICOS CORPORATION | 2002-09-24 | — | — | US | disclosed |
| US-6423710-B1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION | 2002-07-23 | — | — | US | disclosed |
| US-6376489-B1 | PHENYL OR BENZYLPYRROLIDINE DERIVATIVES | ICOS CORPORATION | 2002-04-23 | — | — | US | disclosed |
| US-20020032224-A1 | Treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system disorders | ICOS CORPORATION | 2002-03-14 | — | — | US | disclosed |
| US-6294561-B1 | ENZYME INHIBITORS FOR CENTRAL NERVOUS SYSTEM (CNS) DISORDERS | ICOS CORPORATION | 2001-09-25 | — | — | US | disclosed |
| US-6258833-B1 | ENZYME INHIBITORS AND ANTIINFLAMMATORY AGENTS | ICOS CORPORATION | 2001-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169196-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | PDE4A, PDE4B, PDE4C | PDE4A 1/4885PDE4B 2/4885PDE4C 3/4885 |
| US-20040023945-A1 | CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE7A | PDE4A 1/4885PDE4B 2/4885PDE4C 4/4885 |
| US-20040152754-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | PDE4A, PDE4B, PDE7A | PDE4A 1/4885PDE4B 2/4885PDE4C 4/4885 |
| US-20020032224-A1 | Treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system disorders | PDE4A, PDE4B, PDE4C | PDE4A 1/4885PDE4B 2/4885PDE4C 3/4885 |
| US-20060074123-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | PDE4A, PDE4B, PDE7A | PDE4A 1/4885PDE4B 2/4885PDE4C 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.