Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.40 |
| ▸ | PLD2 | O14939 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374205 | 0.92 | HDAC6 (0.45) | SCN9ACHRM2GRIN2BMEN1KMT2A | |
| SCHEMBL7369193 | 0.81 | CHRM2 (0.51) | CHRM2GRIN2BMEN1KMT2AGRIN1 | |
| SCHEMBL7373279 | 0.76 | SLC6A2 (0.51) | SCN9AGRIN2BMEN1KMT2AGRIN1 | |
| SCHEMBL7376190 | 0.76 | SCN9A (0.55) | SCN9AGRIN2BMEN1KMT2AGRIN1 | |
| SCHEMBL5369718 | 0.74 | HDAC6 (0.48) | SCN9AGRIN2BMEN1KMT2AGRIN1 | |
| SCHEMBL5735093 | 0.74 | HDAC6 (0.49) | SCN9AGRIN2BMEN1KMT2AGRIN1 | |
| SCHEMBL5365819 | 0.74 | HDAC6 (0.44) | CHRM2GRIN2BMEN1KMT2AGRIN1 | |
| SCHEMBL5369714 | 0.72 | GPR84 (0.48) | GRIN2BMEN1KMT2AGRIN1GRIN2D | |
| SCHEMBL5374691 | 0.71 | GAA (0.47) | GRIN2BMEN1KMT2AGRIN1GRIN2D | |
| SCHEMBL5378033 | 0.70 | SLC6A2 (0.45) | GRIN2BMEN1KMT2AGRIN1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |