SCHEMBL5370532

SCHEMBL5370532

N#CCC(=O)NC[C@H]1CN(c2cc(F)c(C3[C@H]4C[S+]([O-])C[C@@H]34)c(F)c2)C(=O)O1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 5/20 0.42
MAOB P27338 4/20 0.42
LMNA P02545 1/20 0.42
PTGS1 P23219 1/20 0.42
CALML3 P27482 1/20 0.42
SDHA P31040 1/20 0.42
F10 P00742 9/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14370659 1.00 MAOA (0.42) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL14370656 0.89 MAOA (0.46) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5380268 0.89 MAOA (0.46) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL14370626 0.88 MAOA (0.46) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5382628 0.88 MAOB (0.48) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL14370661 0.88 MAOB (0.48) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL4880125 0.88 MAOA (0.46) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL14370667 0.86 MAOA (0.45) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL4883459 0.85 MAOA (0.57) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5378628 0.84 MAOB (0.58) MAOAMAOBLMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 US claimed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 US claimed
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 US disclosed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues OXA1L, CYP51A1, CYP2C19 MAOA 1957/4885MAOB 1797/4885LMNA 3131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.